About this role
Project advert Anorexia and cachexia, associated with malignancy, are commonly observed in metastatic cancer patients yet remain poorly understood. Metastatic upper gastrointestinal cancer patients who are anorexic at baseline have poorer clinical outcomes compared to those who are not anorexic at baseline. The mechanisms involved are unclear. The gut microbiome has an important influence on human health and the development of chronic diseases including some cancers, but the role of the gut microbiota in modulating treatment responses and upper gastrointestinal cancer progression remains unclear. This is an exciting project suitable for an enthusiastic and passionate PhD candidate aiming to explore the mechanisms involved in driving anorexia/cachexia and links with the gut microbiome. The successful candidate will have support from the University Doctoral College and be part of the Department of Life Sciences, based in the newly opened Dalton Building in central Manchester. The proj...