About this role
苏州，中国 | 全职 | Job ID: 11912
About the role
As Manager or Senior Manager, In Vivo Pharmacology, you will lead oncology studies that help BioNTech assess treatment approaches and make informed decisions about candidate development. Your expertise in complex tumor models will help connect study findings to our work developing new approaches to address cancer. Reporting to the Head of In Vivo Pharmacology, you will guide a research team and partner with colleagues across Drug Discovery. You'll shape study plans, interpret results and support rigorous, timely research, with a strong focus on animal welfare and data quality.
Your contribution: Lead and develop the in vivo pharmacology team, setting priorities and allocating resources to deliver study milestones Establish, characterize and qualify complex tumor models, selecting models that fit each research question Design and oversee oncology efficacy and combination studies with clear hypotheses, controls, endpoints and robust study methods Coordinate pharmacodynamic and mechanism-of-action studies, integrating tumor response, biomarkers and pharmacokinetic and pharmacodynamic dataInterpret findings, communicate model limitations and recommend next steps to support candidate selection and project decisions Ensure high standards for animal welfare, study records and data quality; oversee external research partners and study delivery A good match: Bachelor's degree or higher in pharmacology, oncology, veterinary medicine, immunology, biology or a related discipline; an advanced degree is preferred Hands-on experience developing, characterizing and applying complex tumor models, such as orthotopic, metastatic, patient-derived xenograft, syngeneic or humanized mouse models Experience independently designing, executing, troubleshooting and interpreting oncology efficacy studies, including statistical planning and pharmacodynamic endpoints People-management experience leading in vivo pharmacology or related research teams, including staff development, resource planning and oversight of concurrent studies or external research organizations Strong understanding of tumor biology and the tumor microenvironment, with experience integrating efficacy, tolerability, biomarker and pharmacokinetic and pharmacodynamic data Knowledge of animal welfare, ethics review, humane endpoints and the 3Rs, plus strong planning and communication skills and the ability to discuss scientific work in EnglishAt Senior Manager level, broader leadership across multiple projects and experience developing team capabilities are expected.
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