About this role
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Working in the laboratory of Professor Thomas Durcan, the candidate will work on a postdoctoral research project that will investigate the emerging roles of cell-surface RNA-binding proteins (csRBPs), with a primary focus on TDP-43, in amyotrophic lateral sclerosis (ALS). Building on preliminary evidence that ALS-linked RBPs including TDP-43, FUS and TAF15 localize to the outer surface of cells and form cell-surface ribonucleoprotein (csRNP) nanoclusters, the project will examine how these assemblies are organized in neuronal models, how ALS-associated mutations alter their properties, and how csRBPs may contribute to the intercellular transmission of neurotoxic signals. Studies will use human iPSC-derived motor neurons and complementary cellular models together with high-resolution imaging, live-cell labeling/ flow cytometry, cell-surface and proximity-labeling proteomics, molecular perturbation, and functional assays. The project will also investigate genetic and molecular determinants of csRBP surface targeting, including through CRISPR-based screening, and test the role of csTDP-43 in extracellular cargo entry and cell-to-cell transfer.
Qualifications: PhD obtained
This position is covered by the AMURE collective agreement https://www.mcgill.ca/hr/files/hr/collective_agreement_-_post_docs_-_2023-2026_-_final_-_with_signture.pdf
Before applying, please note that to work at McGill University, you must be both authorized to work in Canada and willing to work in the province of Quebec at the campus where the position is based / located.
McGill University is an English-language university where most teaching and research activities are conducted in the English language, thereby requiring English communication both verbally and in writing.
McGill University is committed to equity and diversity within its community and values academic rigour and excellence. We welcome and encourage applications from racialized persons/visible minorities, women, Indigenous persons, persons with disabilities, ethnic minorities, and persons of minority sexual orientations and gender identities, as well as from all qualified candidates with the skills and knowledge to engage productively with diverse communities.
At McGill, research that reflects diverse intellectual traditions, methodologies, and modes of dissemination and translation is valued and encouraged. Candidates are invited to demonstrate their research impact both within and across academic disciplines and in other sectors, such as government, communities, or industry.
McGill further recognizes and fairly considers the impact of leaves (e.g., family care or health-related) that may contribute to career interruptions or slowdowns. Candidates are encouraged to signal any leave that affected productivity, or that may have had an effect on their career path. This information will be considered to ensure the equitable assessment of the candidate’s record.
McGill implements an employment equity program and encourages members of designated equity groups to self-identify. It further seeks to ensure the equitable treatment and full inclusion of persons with disabilities by striving for the implementation of universal design principles transversally, across all facets of the University community, and through accommodation policies and procedures. Persons with disabilities who anticipate needing accommodations for any part of the application process may contact, in confidence, accessibilityrequest.hr@mcgill.ca.
All qualified applicants are encouraged to apply; however, in accordance with Canadian immigration requirements, Canadians and permanent residents will be given priority.