About this role
The job holder will help develop and validate analytical methods to support NML measurement research programmes for government. They will also assist private sector R&D contract commitments related to protein analysis. They must use advanced instruments and apply various sample preparation techniques as needed.
The successful candidate will have experience in protein structural characterisation and, likely quantification by mass spectrometry. Training as needed will be provided on traceability of measurements to the System of International Units and on the instruments necessary for the delivery of the projects. This is an excellent opportunity for candidates seeking to advance their career in protein mass spectrometry.
Key Responsibilities
Independent day-to-day planning and delivery of challenging research and development work, ensuring quality, timely delivery, and adherence to budgetLead and manage protein and peptide metrology projects, concentrating on protein structural analysis through mass spectrometryPublication and dissemination of scientific advancements and achievementsProvide support in formulating R&D commercial contractsBuild and nurture relationships with external partners and collaborators, and extend metrology networks to underpin the UK national measurement systemDelivery of ad-hoc research commercial projects and comprehensive reporting of results Knowledge, Experience and Technical Skills
PhD (or equivalent experience) in industry, academic, or clinical researchDemonstrated expertise in protein structure characterization methods involving mass spectrometry, such as HDX-MS, native MS, IMS, and XL-MSExpertise in the development and optimisation of protein characterisation methods, particularly intact mass analysis and peptide mapping for the assessment of purity, homogeneity and stabilityExperience on quantification approaches for peptides and proteins is highly desirableSolid knowledge of protein chemistry and related workflows, encompassing peptide and protein sample preparation, treatment, and handlingExperience in peptide and protein separation and purification methods, including HPLC, SPE and dialysisProficiency in mass spectrometry instrumentation, operation and maintenance (e.g. Orbitrap and qTOF platforms including ion mobility applications)Familiarity with bioinformatics tools and databases for protein identification and structural characterisationStrong data analysis and interpretation skills, particularly for protein mass spectrometry dataExcellent written and verbal communication and presentation skillsExperience in managing and carrying out long-term and short-term research projects, adhering to deadlines, and producing high-quality technical reportsPerson Specification
The role requires an enthusiastic scientist who will contribute to the successful delivery of analytical R&D projects. You are encouraged to share your achievements through relevant scientific publications, reports and presentations. The following person specifications are required:
Capacity to handle both extended and brief projectsPassionate and innovative scientistSelf-reliant and self-motivated great teammateExcellent interpersonal skillsStrong attention to detail and a proactive attitude towards learningAppreciation for working within a quality system and knowledge of good laboratory practiceThe job holder will be able to demonstrate the following behaviours in line with LGC’s values:
Passion, Curiosity, Integrity, Brilliance, Respect
About The National Measurement Laboratory
Measurement matters, as it affects everything from food and drink to medicine.
At the NML we have a strong heritage in measurement science. We are the UK’s designated institute for chemical and bio measurement, and the home of the Government Chemist.
The Government Chemist role was created in 1909 and now it oversees the statutory function of referee analyst within the UK, resolving disputes over analytical measurements, particularly in relation to food regulatory enforcement.
The UK was one of the pioneers within the global measurement community to recognise the need to address the new and developing challenges of measurement across chemistry and biology. In 1988, the then Government Chemist launched the first UK programme to develop a chemical and bio-measurement infrastructure and the NML was born.
https://www.lgcgroup.com/uk-national-measurement-laboratory/
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Our Benefits
25 days annual leave, generous pension plan, season ticket loans, buy/sell holiday scheme, life assurance, retail discounts and more.