About this role
Role Overview:
Legend Biotech is a clinical stage biopharmaceutical company focused on the discovery and development of novel cell therapies for oncology, immunology and infectious disease indications. We are currently seeking talented and motivated individuals to join the group of Cell Biology and Immunology in the R&D Department located at Piscataway of New Jersey. The successful candidate should possess extensive knowledge and hands-on experience in oncology, cell biology and immunology, in particular TCR-T/CAR-T cell biology. The candidate will be able to contribute to the effort for developing T cell therapy platform, building and optimizing cell-based immunoassays to characterize and assess TCR-T/CAR-T cell functions. Experience with TCR-T/CAR-T cells is preferred. As major contributors of pipeline development, the candidates need to demonstrate the ability of planning, designing, executing complicated experiments and delivering scientific results in a cross-functional environment. This position also requires supervision and management skills.
Major Responsibilities:
Independently plan, design, execute experiments to assess the in-vitro functions of TCR-T/CAR-T cellsDevelop T cell therapy platform and optimize cell-based immunoassays, including ex-vivo antigen-specific T cell isolation and expansion. Multi-color flow cytometry, ELISA, ELISPOT, cytotoxic assaysDeliver scientific results at internal and external meetingsSupervise associate scientists for routine laboratory workHelp group leader for general laboratory managementServe as the major contributors for pipeline development Education:
PhD in cell biology/ImmunologyExperience:
>3 years’ post-graduate experience in human T-cell biology and immunologyExtensive hands-on experience in TCR-T/CAR-T cell for cancer immunotherapy>1 years’ supervisory experienceKey Capabilities, Knowledge, and Skills:
Extensive knowledge and hands-on experience in TCR-T/CAR-T field. Experience in immune-oncology preferredExpertise in cell biology and immune cell profiling. Extensive experience in multi-color flow-cytometryHands-on experience and troubleshooting proficiency with immune cell isolation from peripheral blood and leukopak, expansion, and cell based immunoassaysExperience with dendritic cell culture and DC-T cell cocluture for antigen-specific T cellExperience with lentivirus/retrovirus preparation, titration and T cell transductionExperience in CRISPR/CAS-9 for gene knock-out and knock-inTrack record of scientific publications and accomplishmentsDemonstrated ability in presenting scientific resultsExcellent oral and written communication skillsA team player who can work efficiently as an individual Legend Biotech USA Inc. is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by law.
Legend Biotech USA Inc. maintains a drug-free workplace.