About this role
Lead and execute genomic safety assessment packages for gene editing therapeutics, spanning off-target discovery, verification/validation, and genomic integrity characterization.Apply and evaluate a range of off-target discovery approaches, including in silico tools (CALITAS, CRISPRMe, CasOFFinder), biochemical methods (SITE-seq, CIRCLE-seq, CHANGE-seq, Digenome-seq), and cell-based assays (GUIDE-seq, INDUCE-seq).Drive off-target verification and validation using amplicon-based sequencing approaches such as AmpSeq, rhAmpSeq, and hybrid capture sequencing.Characterize genomic integrity using orthogonal methods including karyotyping, optical genome mapping, and WGS.Assess genotoxicity potential of next-generation genome engineering modalities (base editors, prime editors) using modality-appropriate off-target assessment strategies.Contribute to or lead novel assay development efforts to interrogate emerging genome editing modalities (Gen 5+)Integrate biodistribution data to guide tissue selection for off-target verification studies Minimum Required Qualifications:
B.S. in genomics, molecular biology, biochemistry, or a related field with 5+ years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics. M.S. in genomics, molecular biology, biochemistry, or a related field with 3-7 years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics. Ph.D. in genomics, molecular biology, biochemistry or related field with 2-4 years of industry experience in off-target assessment and/or genomic safety evaluation for gene editing therapeutics.Proficiency with CRISPR-based genome editing and familiarity with a broad range of off-target discovery platforms.Experience with next-generation sequencing workflows and data interpretation.Familiarity with emerging modalities such as base editing and prime editing, and their associated genotoxicity considerations.Strong track record of scientific problem-solving, with experience in assay development being a plus.Excellent written and verbal communication skills; ability to present complex data to cross-functional teams.Ability to work independently and as a part of a team, self-motivation, adaptability, and a positive attitude.Preferred Qualifications:
Experience with optical genome mapping (Bionano platform).Familiarity with regulatory expectations around genomic safety packages for IND/BLA submissions.Experience with human diversity-dependent off-target discovery approaches (e.g., ONE-seq).Authorization to work in the United States indefinitely without restriction or sponsorship.
The position is Full Time, Monday-Friday, 8 am-5 pm. Candidates currently living within a commutable distance of Boston, MA, are encouraged to apply
What to Expect in the Hiring Process:
10-15 Minute Phone Interview with Regional Recruiter45-60 Minute Virtual Interview with Manager and/or Group Leader45-60 Minute In-Person Meeting for a Casual Discussion of the RoleWhat We Offer:
Excellent full-time benefits, including comprehensive medical coverage, dental, and vision optionsLife and disability insurance401(k) with company matchPaid vacation and holidaysYearly goal-based bonus & eligibility for merit-based increasesAnnual Compensation is $104,000 - $112,320, depending on education and experience Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.