About this role
Salary: Full time starting salary is normally in the range £36,636 to £46,049 with potential progression once in post to £48,822. Grade: 7
Contract Type: Fixed Term contract up to January 2029
This Wellcome Trust-funded post is established to study the mechanisms of transcriptional control of mRNA fate in development. The post holder will be part of a multi-disciplinary research team within the Department of Cancer and Genomic Sciences. Their main role will be to apply and develop new methods of precise genome manipulation and subsequent in vivo phenotyping (e.g. high resolution 4D imaging) and molecular analysis (transcriptomics, metabolomics) of zebrafish embryo models. They will develop transgenic and mutant models for transcriptional regulation of post-transcriptional mRNA fate focussing on transcription initiation dependent mRNA diversification. They will answer questions about how transcription control on promoter level contributes to metabolic adaptation and response to metabolic stress in development. They will perform and develop assays for in vivo detection of metabolic shifts by transgenic and other reporter activity and will work together with genomics experts and those seeking mechanism of translation regulation of mRNAs in the same programme. The post is available for 3 years.
Role Summary
Work within specified research grants and projects and contribute to writing bids Operate within area of functional genomics and developmental genetics Analyse and interpret research findings and results by embryo phenotyping by genomics and imaging tools, publish high quality new results in peer reviewed journals Contribute to generating funding for further research in the area Contribute to licensing or spin out deals with demonstrated commercial success (such as revenues, asset or company sales, IP generated) and/or public understanding of the discipline or similar
Main Duties
The responsibilities may include some but not all of the responsibilities outlined below.
Develop research objectives and proposals for own or joint research, with assistance of a mentor if required Contribute to writing bids for research funding Analyse and interpret genomics, embryo phenotyping and developmental genetic data Apply knowledge in a way which develops new intellectual understanding of transcription control Disseminate research findings for peer reviewed publication, research seminars conferences and consortium meetings Supervise students on wet lab research and provide guidance to PhD students where appropriate to the developmental genetics, functional genomics Contribute to developing new models, techniques and methods in genome editing and manipulation, in vivo phenotyping
Person Specification
First degree in biology or related subject and normally, a PhD in biomedical research area or equivalent qualifications High level analytical capability Ability to communicate complex information clearly Fluency in embryo model (preferably zebrafish) associated genome manipulation techniques or methods and ability to contribute to developing new ones including: embryo molecular phenotyping and in vivo imaging
Informal enquires can be made to Ferenc Mueller [email protected]
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