About this role
About the role
We are seeking a full-time time highly motivated post-doctoral research associate to join Prof Edan Foley’s group in the Department of Life Sciences at the University of Bath.
Prof Edan Foley’s group is currently focusing on the effects of commensal and pathogenic bacteria on intestinal homeostasis in the zebrafish model. The group is particularly interested in understanding how BEST4 cells shape host responses to pro-inflammatory challenges. BEST4 cells are a recently identified intestinal epithelial cell type with putative roles in the regulation of intestinal pH and mucus hydration. However, we have minimal understanding of the relationships between BEST4 cells and inflammatory challenges in a live animal model.
This job purpose can be summarised as follows:
Working with larval and adult zebrafish characterize the impacts of pro-inflammatory challenges on BEST4 cell function in the gut. Determine the consequences of BEST4 cell ablation for host responses to intestinal inflammation. Using genetic and genomic methodologies, characterize the transcriptional states of BEST4 cells as the intestine experiences and recovers from an inflammatory challenge.
About you
Our ideal candidate will have:
A PhD or equivalent in a relevant subject Experience working with animal models of intestinal development and homeostasis. Experience working with intestinal responses to injurious challenges, particularly in the context of genetic manipulation of the host. Bioinformatic expertise in the characterization of intestinal cell types that express fluorescent markers of interest. Publications in a relevant field.
Further information
For an informal discussion relating to this role, please contact Prof Edan Foley ([email protected]), or, Prof David Tosh ([email protected])
This is a full-time(36.5 hours), fixed-term contract for 24 months
As a member of Research Staff at the University of Bath, you will be encouraged to take up a minimum of 10 days professional development pro rata per year
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