About this role
We are seeking a process development scientist to join the guide-RNA (gRNA) process development team. The successful candidate will be contributing to gRNA drug substance process development for programs in clinical development. In this role, the candidate will synthesize, purify, and characterize gRNAs in an effort to develop drug substance manufacturing processes and controls.
Execute solid-phase synthesis and purification experiments to support process development, scale-up, and transfer of oligonucleotide drug substance manufacturing.Execute routine analytics including HPLC and UV-Vis.Prepare buffers, reagents, and stock solutions used for process development activities, following established recipes and SOPs.Compile and present data to team members and key stakeholdersMaintain an updated lab notebook, order materials, maintain lab equipment, and support equipment troubleshooting as needed.Uphold lab safety to the highest level of standards. Minimum Required Qualifications:
B.S./M.S. degree in chemistry, chemical engineering, or biochemistry (or related field) with at least 2 years of relevant laboratory industry experienceExperience with oligonucleotide synthesis and purification equipment (experience with gRNA or longmer synthesis and purification development is a plus)Experience operating analytical equipment such as Akta chromatography systems, Agilent U/HPLC, gel electrophoresis, and NanoDrop.Ability to follow established SOPs for routine analytical support.Experience with good documentation practices and electronic lab notebooks such as Benchling.Unwavering commitment to safety protocols and procedures.Strong attention to detail, organizational, and time-management skills.Effective communication skills for collaborating with team members and conveying technical information clearly.Strong problem-solving abilities and critical thinking skills.Inquisitive, analytical, laboratory technique familiarity, enthusiasm to learn and contribute in a fast-paced environment.Preferred Qualifications:
Background in CRISPR gRNA development.Authorization to work in the United States indefinitely without restriction or sponsorship. The position is full-time, Monday-Friday, 8am-5pm with overtime as needed. Candidates living within a commutable distance of Boston, MA are encouraged to apply.
Excellent full-time benefits include:
Comprehensive medical coverage, dental, and vision optionsLife and disability insurance401(k) with company matchPaid vacation and holidaysEligibility for yearly goal-based bonus & merit-based increasesCompensation: $32.00-$41.00 per hourEurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.