About this role
We are seeking a Scientist – Off-Target Genomics (Gene Therapy) to lead and execute genomic safety assessment strategies for gene editing therapeutics. This role focuses on evaluating off-target effects, genomic integrity, and emerging genome editing modalities.
Key Responsibilities:
Lead genomic safety assessment packages, including off-target discovery, verification, validation, and genomic integrity characterizationApply and evaluate off-target discovery approaches using:In silico tools (e.g., CALITAS, CRISPRme, Cas-OFFinder)Biochemical methods (e.g., SITE-seq, CIRCLE-seq, CHANGE-seq, Digenome-seq)Cell-based assays (e.g., GUIDE-seq, INDUCE-seq)Drive off-target confirmation using sequencing-based approaches such as AmpSeq, rhAmpSeq, and hybrid captureAssess genomic integrity using orthogonal platforms including karyotyping, optical genome mapping, and whole genome sequencing (WGS)Evaluate genotoxicity risks associated with next-generation genome editing technologies, including base and prime editingSupport and/or lead development of novel assays for emerging genome editing modalities (Gen 5+)Integrate biodistribution data to inform tissue selection for off-target verification studiesCollaborate cross-functionally and present findings clearly to scientific and project teams Minimum Qualifications:
B.S. with 5+ years, M.S. with 3–7 years, or Ph.D. with 2–4 years of industry experience in genomics, molecular biology, biochemistry, or a related fieldHands-on experience in off-target assessment and/or genomic safety evaluation for gene editing therapeuticsStrong working knowledge of CRISPR-based genome editing technologiesExperience with next-generation sequencing workflows and data interpretationFamiliarity with base editing, prime editing, and associated genotoxicity considerationsDemonstrated scientific problem-solving skills; assay development experience is a plusStrong communication skills with the ability to present complex data to diverse audiencesSelf-motivated, adaptable, and able to work both independently and collaborativelyPreferred Qualifications:
Experience with optical genome mapping (e.g., Bionano platform)Understanding of regulatory expectations for genomic safety (IND/BLA submissions)Exposure to human diversity-informed off-target methods (e.g., ONE-seq)Authorization to work in the U.S. without sponsorship The position is Full Time, Monday-Friday, 8 am-5 pm. Candidates currently living within a commutable distance of Boston, MA, are encouraged to apply
What to Expect in the Hiring Process:
10-15 Minute Phone Interview with Regional Recruiter45-60 Minute Virtual Interview with Manager and/or Group Leader45-60 Minute In-Person Meeting for a Casual Discussion of the RoleWhat We Offer:
Excellent full-time benefits, including comprehensive medical coverage, dental, and vision optionsLife and disability insurance401(k) with company matchPaid vacation and holidaysYearly goal-based bonus & eligibility for merit-based increasesAnnual Compensation is $104,000 - $112,320, depending on education and experience Eurofins USA PSS Insourcing Solutions is a Disabled and Veteran Equal Employment Opportunity employer.