About this role
About Us
The post will be based at Guy’s Campus of King’s College London. The successful candidate will work with Professor James Arnold (https://www.linkedin.com/in/james-arnold-1a0497263/) and be part of the Tumour Immunology Group (https://www.kcl.ac.uk/research/tumour-immunology-group).
About The Role
A Postdoctoral Research Associate position is open in the Tumour Immunology Group at King’s College London run by Professor James Arnold (https://www.kcl.ac.uk/research/tumour-immunology-group).
This project, funded by the Little Princess Trust, will focus on advancing switchable Chimeric Antigen Receptor (CAR) technology incorporating tumour microenvironment (TME) modulating payloads. The overarching goal is to overcome the key barriers limiting CAR T-cell efficacy in solid tumours, particularly neuroblastoma, by enabling tumour-restricted activation while simultaneously modulating the TME to support robust and sustained anti-tumour responses.
A major focus of the project will be on understanding the role of macrophages within the TME, including their contribution to immune suppression, tumour progression, and resistance to immunotherapy. The successful candidate will investigate strategies to reprogramme tumour-associated macrophages and reshape the broader stromal and immune landscape, with the aim of identifying CAR T-cell approaches that are both highly effective and exhibit minimal off-tumour toxicity.
The position will be primarily based at King’s College London, Guy’s Campus, offering access to a highly collaborative and interdisciplinary research environment. The project is conducted in close collaboration with Professor John Anderson and Dr Thomas Jackson at UCL and the Great Ormond Street Institute of Child Health, providing strong translational links to paediatric oncology and clinical application.
The project will employ a broad range of experimental approaches, including in vivo models of neuroblastoma to assess therapeutic efficacy and safety of the CAR approaches, alongside ex vivo and in vitro analyses to dissect cellular and molecular mechanisms. Techniques will include multiparametric flow cytometry, immunofluorescence and advanced imaging, transcriptomic profiling and in vivo and ex vivo CAR generation. Integration of these datasets will enable a systems-level understanding of this novel CAR T-cell approach for the treatment of neuroblastoma and guide the rational design of improved therapeutic strategies.
This project offers an exciting opportunity to contribute to a highly translational research programme aimed at developing safer and more effective CAR T-cell therapies for paediatric solid tumours, with clear potential for clinical impact.