About this role
We are inviting applications for a Postdoctoral Research Fellow position, funded by a Medical Research Council (MRC) Grant. This role offers an exciting opportunity to contribute to a cutting-edge project investigating the interplay between epigenetics and metabolism in embryonic stem cells (ESCs). Metabolic pathways supply essential metabolites for chemical modifications of chromatin, ultimately affecting gene expression. However, there is a fundamental gap in our knowledge about the molecular mechanisms through which cell metabolism affects chromatin modifications in pluripotent stem cells and how these processes are coordinated during early development. We recently discovered that pluripotent stem cells have an unusual metabolism and, unlike adult cells, use specific nutrients (betaine) to drive their metabolism (one carbon metabolism). Interestingly, mutations of the one carbon (1C) metabolism are associated with inborn errors of metabolism such as homocystinuria patients. These...