About this role
We are looking for support in our Immunomodulation unit to start as soon as possible. The successful candidate has the objective to be involved in novel antigen discovery project, potentially TCR deorphanisation, providing a bridge between bioinformatic prediction and wet lab validation, design, plan and analyse complex immunological assays, coordinating technical personnel in execution of experiments.
Design, planning, execution, and scientific interpretation of complex in vitro preclinical immunology studies, including:
Primary human T cell in vitro priming
Antigen re-stimulation of primary patient samples (re-call stimulation)
Immunological assays such as ELISpot/FluoroSpot and multicolor flow cytometric analyses, functional T cell profiling, cytotoxicity assays
TCR construct design
Plan and coordinate in vivo immunogenicity screening and xenograft studies
Establish, optimize, and standardize new immunological methods and assay platforms, including evaluation of emerging technologies for instance high-throughput antigen-discovery or CRISPR screens
Independent analysis and interpretation of experimental data, including integration of multi-parameter immunological readouts
Documentation, reporting, and communication of experimental results in compliance with internal standards and regulatory guidelines
Manuscript and grant writing
Contribute to cross-functional project success in close collaboration with bioinformaticians, immunologists, and other collaborateurs
Completed degree in biology or a related discipline; PhD in a relevant field such as human T cell immunology or T cell-based cancer immunotherapy, vaccinology
Strong expertise in human T cell in vitro assays, including T cell in vitro priming or recall stimulation; experience with human T cell expansion and genetic modification is highly desirable
Experience with patient-derived xenograft (PDX) models and adoptive cell transfer is an advantage
Strong expertise in screenin literature and integrating new discoveries
Excellent communication skills and ability to work in interdisciplinary teams
Very good command of English (written and spoken) Enthusiasm and curiosity for the diverse activities of our research institute as well as the ability to work in a team completes your profile.
A dynamic, innovative and creative research environment
An open, collegial and cordial working atmosphere in a respectful corporate culture
A high degree of diversity in the workforce
Flat hierarchies
Performance-related remuneration and other benefits
The opportunity for personalised further training
Job ticket (Deutschlandticket) incl. employer allowance
Bike leasing (Businessbike)
Wellhub
The opportunity for hybrid working