About this role
Work Area: Institute for Experimental Tumour Therapy Job ID: 13914 Start Date: Next possible date Work Scope: Parttime (25,025 hours per week) Contract Type: Temporary contract Contract duration: 30. June 2030; in accordance with § 2 (2) WissZeitVG for the duration of the project
Your tasks
Opportunity to conduct high-level interdisciplinary research within the newly established DFG funded Collaborative Research Centre CRC/SFB 1752 “DYNAMO”, investigating the earliest mechanisms of therapy resistance in melanoma during the first days and weeks after therapy initiation:
- Work in Project B01
- Deciphering fibroblast heterogeneity and its implications for immune checkpoint inhibitor response in melanoma
- Investigation of fibroblasts, melanoma, and T cell interactions in the context of immune checkpoint inhibitor (ICI) response and resistance in melanoma
- Multiplex imaging and spatial characterization of tumor–immune interactions
- Contribution to experimental design and execution of immune-oncology focused and in vitro and ex vivo functional assays
- Gene expression analyses (e.g. qPCR) and cytokine/chemokine profiling in tumor immune interaction models
- Data analysis, interpretation, and integration of experimental results in collaboration with computational project partners
- Participation in presentation of scientific results at meetings and conferences
Your profile
- Completed Diploma or Master degree in molecular biology or cancer biology, immunology, cell biology, bioinformatics, translational medicine or related disciplines
- Strong interest in melanoma biology, tumor immunology, immune checkpoint therapy, translational cancer research, and tumor–immune interactions
- Strong interest in multiplex/spatial imaging approaches (e.g. Phenocycler or related platforms)
- Experience in molecular and cellular biology techniques
- Experience with cell culture, cytokine profiling, flow cytometry and/or microscopy is desirable
- Experience with bioinformatics or biostatistics is advantageous
- Ability to work independently and in interdisciplinary teams, specifically bridging melanoma biology and tumor immunology
- Ability to work closely with the second B01 project team and contribute to active scientific exchange
- High level of self-motivation, scientific curiosity, reliability, personal initiative, creativity, and team-oriented personality
- Enthusiasm for hands-on experimental and computational research and active contribution to a dynamic, international, and collaborative research environment
- Strong organizational skills, commitment, and the ability to drive projects forward independently
- Fluent in spoken and written English
Your application should include
- Letter of motivation describing research interests and motivation for joining the project
- Curriculum vitae (CV) including publication list, if applicable
- Copies of academic certificates and transcripts
- Contact details of TWO academic referees or letters of recommendation Look forward to:
- Cutting-edge research & technology innovative project:
- Participation in a newly established DFG-funded Collaborative Research Centre featuring a strong interdisciplinary translational focus on tumor dynamics and immune modulation in melanoma
- Access to state-of-the-art technologies including spatial transcriptomics, multiplex imaging, cytokine/chemokine profiling, confocal microscopy and AI-supported data integration
- Networking & collaboration in the scientific community:
- Integration into an interdisciplinary, internationally visible cancer immunology research network
- Diverse teams: daily interaction with professional colleagues across experimental, computational, and clinical research
- Exchange opportunities: excellent avenues for close scientific collaboration and external career development
- Mentoring & career development: Structured guidance: continuous, high-quality mentoring tailored to your academic progression
- Enrollment into the Graduate School for Biomedical Science ‘BIOME’ ( https://www.uni-due.de/biome /)
- Skill building: active participation in CRC events, lab rotations, hands-on workshops, and specialized training activities
- Work environment & infrastructure: Top-tier facilities: excellent institutional infrastructure located directly at the University Hospital Essen campus
- A secure job in the public service of the state of NRW
- Fair payment in accordance with the collective wage agreement (TV-L) incl. annual bonus payment and supplementary company pension scheme
- 30 days of vacation per calendar year (for a full-time position)
- Interdisciplinary work with colleagues from other departments
- Working with modern equipment and certified quality standards
- Family-friendly corporate culture, e.g. company daycare center, vacation program for school-age children, advice and support from the Employee Service Office in all life situations
- Wide range of training and continuing education opportunities, e.g. at the Training Academy of UK Essen
- Health Management, e.g. company integration management, vaccinations, promotion of sports activities
- Attractive fringe benefits, e.g. reduced-price canteen meals, community events, accommodation in student residences.
General conditions
- The pay grade classification depends on the personal and collective legal prerequisites.
- The University Hospital Essen is an equal opportunity employer. Female scientists are particularly encouraged to apply.
- The participation in secondary employment depends on the „Hochschulnebentätigkeitsverordnung“ of North-Rhine Westphalia.
- Disabled applicants will be preferentially considered in case of equivalent qualification.
You will find detailed information on the job advertisement and contact persons behind the button - Apply now: https://bewerbung-karriere.ume.de/Vacancies/13914/Application/CheckLogin/1 We use your data exclusively for application purposes in accordance with the applicable data protection regulations. Further information can be found in the privacy statement on our homepage at: www.uk-essen.de .