About this role
TRACERx EVO involves multi-region whole genome sequence analyses of thoracic cancers from approximately 600 patients, through the disease course from pre-invasive through to primary and metastatic disease, in order to understand cancer evolutionary life histories in this disease. This work is supported by the excellent bioinformatics facilities already available in our Centre together with substantial investment in bioinformatics staff, data storage and computer processing power. Newly discovered driver events are functionally analysed in preclinical models and validated for drug discovery initiatives as part of the Centre’s program.
PEACE is a pan cancer national research autopsy programme in which post-mortem sampling allows access to tissue from all sites of metastasis, and to date has recruited over 400 patients and performed over 200 autopsies. PEACE aims to investigate the biological processes underpinning metastatic disease, including genomic drivers of tumour dissemination and failure of the adaptive immune system. The combination of both TRACERx and PEACE with patient co-recruitment has established an unprecedented resource of multi-regional matched primary and metastatic tissue, and therefore facilitates tissue- and blood-based analyses from diagnosis to death. This is the first national autopsy programme at such scale with a consortium of high calibre scientists and clinicians focussed on various projects relevant to metastasis and drug resistance.
This is an excellent opportunity a self-motivated and enthusiastic individual to join the Translational Cancer Therapeutics (TCT) Lab within the Research Department of Oncology at the UCL Cancer Institute. The Research Coordinator will work as part of a small clinical team to support the TRACERx EVO and PEACE Clinical Studies, and other studies as necessary.
A major component of the post will include explaining the studies to patients in detail and obtaining informed consent, collecting blood and fresh tissue samples in various settings including clinics, operating theatres and radiology and ensuring patients are followed up for the full length of the study. The role will also involve attending the mortuary to collect blood and tissue samples from patients at autopsy. All samples collected will need to be processed, stored and logged to GCLP standards in accordance with current clinical trial regulations.
This post is funded for one year in the first instance.
Applications should include a CV and a Cover Letter: In the Cover Letter, please provide evidence of the essential and desirable criteria in the Person Specification part of the Job Description. (By including a Cover Letter, you can leave blank the 'Why you have applied for this role' field in the application form, which is limited in the number of characters it will allow.)
About you
Prospective candidates must have:
Clinical Trial Experience High level of knowledge of patient follow-up Experience in working with all levels of medical and para-medical staff Experience dealing personally and ethically with patients Experience with the collection and processing of clinical data and biological samples
Full phlebotomy training would be an advantage.
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