About this role
Tacalyx is a biopharmaceutical company developing innovative therapeutics to target tumor-associated carbohydrate antigens (TACAs).
To strengthen our team in Berlin-Adlershof, we are seeking an experienced, enthusiastic, and self-motivated Scientist - Antibody and Protein Biochemistry. This laboratory-based role focuses on the design, expression, purification, characterization and modification of antibodies and recombinant proteins to support therapeutic development. It also includes the coordination and scientific oversight of external research activities. Scientist (m/f/d) -Antibody and Protein BiochemistryFull-time | On-site in Berlin-AdlershofDesign of protein and antibody constructs, including chimeric, humanized and multispecific mAbsChemical and enzymatic modification of antibodies (e.g. fragmentation, labeling and conjugation)Characterization of antibody affinity, integrity, activity and stability using methods such as SPR, ELISA, Western blotting and thermal shift assaysMolecular cloning and expression of recombinant proteins in prokaryotic and mammalian cellsDevelopment and implementation of protein purification workflows using an ÄKTA chromatography systemDocumentation and reporting of results and evaluation of relevant scientific literatureCollaboration in project teams advancing antibodies toward first-in-human studiesCoordination and scientific oversight of projects with external partners (e.g. CROs, academic groups)Essential qualifications: PhD in biological sciences or a related discipline, with substantial hands-on laboratory experienceStrong expertise in antibody and protein biochemistry, including cloning, expression, purification and analytical characterizationPractical experience with protein chromatography and biochemical assaysStrong communication skills in EnglishPreferred qualifications: Relevant postdoctoral or industry experienceProficiency in protein and antibody construct designSkills in HPLC-based method developmentPractical expertise in SPR-based measurements of binding kinetics and affinityFamiliarity with antibody humanizationKnowledge of carbohydrate biologyA permanent, full-time position with a competitive salary and excellent opportunities for professional and personal developmentA diverse, international workforce with a dynamic working environment that fosters creativity, innovation and teamworkThe opportunity to contribute to antibody programs advancing toward first-in-human studiesA performance-based annual bonusRegular company and team eventsA fully employer-funded public transport pass (“Job Ticket”)