US_Scientist I_CO @ Actalent

Job Title: Scientist I / Scientist II Next Generation SequencingJob DescriptionThis role contributes to the development of advanced molecular diagnostic methods that enable personalized, proactive treatments and improved patient outcomes. You will work at the forefront of research and early development, applying cutting-edge next generation sequencing (NGS) technologies to address critical challenges in oncology, genetics, womens health, immunology, and infectious diseases. The position offers the opportunity to solve complex problems in NGS, design innovative sequencing assays, and help invent new diagnostic methods in a highly collaborative, high-performance team environment.

Responsibilities

• Perform cell-free nucleic acid extraction from clinical plasma specimens, whole blood, and formalin-fixed paraffin-embedded (FFPE) tissue with high accuracy and consistency.
• Work under supervisory guidance to plan and conduct hands-on laboratory experiments independently, ensuring adherence to established protocols and quality standards.
• Design, execute, and optimize methylation sequencing workflows, including method development and refinement for improved performance and reliability.
• Analyze experimental data, evaluate results, draw clear conclusions, and propose logical next steps and future experiments based on findings.
• Collaborate closely with molecular biology and bioinformatics teams to evaluate and identify parameters that may impact sequencing performance and assay robustness.
• Execute high-throughput sequencing operations on the AXELIOS 1 sequencer within a core laboratory environment, following best practices for instrument use and maintenance.
• Maintain detailed, accurate records of all experiments, methods, and project-related information to ensure reproducibility and effective knowledge sharing.
• Contribute to troubleshooting and continuous improvement of NGS library preparation, targeted enrichment, and sequencing workflows.
• Communicate findings, progress, and challenges clearly in written reports and oral presentations to cross-functional stakeholders.

Essential Skills

• Strong experience in molecular biology and human diseaserelated fields, with practical experience in laboratory techniques.
• Solid understanding of next generation sequencing (NGS) principles, including library preparation, targeted enrichment, and sequencing workflows.
• Hands-on experience working with nucleic acids, particularly cell-free nucleic acid extraction from clinical specimens.
• Ability to design, execute, and analyze experiments related to methylation sequencing and other NGS-based assays.
• Demonstrated ability to work effectively in teams and collaborate across disciplines such as molecular biology and bioinformatics.
• Excellent written and oral communication skills, including the ability to present data and conclusions clearly to technical and non-technical audiences.
• Self-motivated and passionate about learning, with a strong desire to acquire on-the-job training and expand technical expertise.
• Capability to work independently in a laboratory setting while following supervisory guidance and established protocols.
• Eligibility for job level Scientist I or Scientist II based on relevant industry experience.

Additional Skills & Qualifications

• Experience working in clinical or diagnostic research settings focused on oncology, genetics, womens health, immunology, or infectious diseases.
• Familiarity with high-throughput sequencing operations and core laboratory workflows, particularly on platforms such as the AXELIOS 1 sequencer.
• Comfort with data analysis tools and workflows commonly used in NGS and bioinformatics collaborations.
• Strong organizational skills and attention to detail for maintaining comprehensive experimental records and project documentation.
• Proactive approach to troubleshooting, process optimization, and continuous improvement of laboratory methods.
• Adaptability to a fast-paced, innovation-driven environment and willingness to take on challenging problems in NGS diagnostics.

Work EnvironmentThis position is based in a core laboratory environment focused on research and early development of advanced NGS-based diagnostics. You will work with high-throughput sequencing technologies, including the AXELIOS 1 sequencer, and perform hands-on bench work involving clinical specimens such as plasma, whole blood, and FFPE tissue. The work involves close collaboration with molecular biology and bioinformatics teams in a high-performance, cross-disciplinary setting that values innovation, scientific rigor, and continuous learning. The culture emphasizes teamwork, clear communication, and a strong commitment to improving patient outcomes through cutting-edge molecular diagnostics. Standard laboratory safety practices apply, and appropriate lab attire and protective equipment are required while performing experiments.

Job Type & LocationThis is a Contract position based out of Pleasanton, CA.

Pay and BenefitsThe pay range for this position is $40.00 - $46.00/hr. Individual compensation offered for this position within this range will depend on many factors, including qualifications, skills, relevant experience, job knowledge, geographic location, internal equity, and other pertinent job-related factors. Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:

Medical, dental & vision

Critical Illness, Accident, and Hospital

401(k) Retirement Plan Pre-tax and Roth post-tax contributions available

Life Insurance (Voluntary Life & AD&D for the employee and dependents)

Short and long-term disability

Health Spending Account (HSA)

Transportation benefits

Employee Assistance Program

Time Off/Leave (PTO, Vacation or Sick Leave)

Application DeadlineThis position is anticipated to close on Oct 31, 2026.

Workplace TypeThis is a fully onsite position in Pleasanton,CA.About Actalent

Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 20,000 consultants and 5,000 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500. We are proud to be an Engineering News-Record (ENR) Top 500 Design Firm for our engineering design services and a ClearlyRated Best of Staffing® winner for both client and talent service.

The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email [email protected] for other accommodation options.

San Francisco Fair Chance Ordinance

Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.

Massachusetts Lie Detector

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Use of Artificial Intelligence (AI)

We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.