About this role
Internal link Toxicology ProQR Therapeutics Full-time Posted on Jul 18, 2026 To strengthen our Axiomer Unit, we are looking for a Director Toxicology (full-time) to support our Translational Development portfolio. Location: Leiden, NL (on-site).
The role
ProQR is looking for an experienced Director Toxicology to join the Translational Development team and to provide scientific and strategic leadership for the nonclinical safety assessment of our pipeline. In this role, you will define and execute toxicology strategies that enable the progression of innovative RNA therapeutics from discovery through clinical development. As Director Toxicology, you will work across multidisciplinary project teams and collaborate closely with external partners to ensure robust, science-driven safety packages that support regulatory submissions worldwide. You will play a key role in shaping development strategies while ensuring studies are delivered to the highest scientific, regulatory, and quality standards.
The activities include
- Lead the nonclinical toxicology strategy across multiple research and development programs, ensuring alignment with program objectives and timelines as well as regulatory expectations.
- Provide scientific leadership for the design, execution, oversight, and interpretation of nonclinical safety studies, including GLP toxicology studies conducted at contract research organizations (CROs).
- Develop integrated nonclinical safety packages that support candidate selection, IND/CTA-enabling activities, and clinical development.
- Serve as the toxicology expert on cross-functional project teams, contributing to development strategy, risk assessment, and decision-making.
- Oversee external CROs, including study planning, protocol review, monitoring of study progress, budget management, and timeline adherence.
- Critically review study protocols, reports, and datasets, ensuring high-quality interpretation and inte...