About this role
Post-doc position on Multi-omics Research & laboratorium Amsterdam 32-36 uur Reageer binnen 24 dagen Post-doc position on Multi-omics in hereditary fibrinogen disorders: bridging the genotype-phenotype gap Join the Fibromics consortium! We are looking for a highly motivated post-doc to join the proteomics lab at Sanquin Research, Amsterdam, the Netherlands within the international Fibromics consortium sponsored by an Innovation Grant from the European Hematology Association. Patients with hereditary fibrinogen disorders are clinically challenging due to unpredictable bleeding and thrombosis conditions. Current diagnostic tools do not identify patients at risk, and management remains largely opinion-based. This project aims to bridge expertise in fibrinogen biology, clinical phenotyping, mass spectrometry-based proteomics and fibrin network analysis to define the phenotype-specific molecular signatures underlying congenital fibrinogen disorders. You will combine plasma, fibrin clot and platelet proteomics with protein variant mapping, fibrinogen proteolysis assays, fibrin network structure analysis, genetic data and clinical characteristics from a well established clinical cohort of individuals with congenital fibrinogen disorders. We offer a diverse and multidisciplinary research environment. The Fibromics consortium brings together large international patient cohorts and leading researchers in hemostasis, proteomics, bioinformatics, and clinical hematology, including Dr. Alessandro Casini (Geneva, Switserland), Prof. Dr. Giancarlo Castaman (Florence, Italy), Dr. Saskia Schols (Nijmegen, the Netherlands) and Dr. Tomáš Šimurda (Martin, Slovakia). You will work alongside fundamental researchers, clinicians, data scientists and specialized laboratory staff, offering a unique combination of patient care, state of the art techniques and insight in the molecular mechanisms of congenital fibrinogen disorders. Candidate profile...