About this role
PhD candidate 'Quest for genetic causes of bleeding tendency'. Radboud UMC · Nijmegen Over de vacature - 36 uur per week - parttime - Schaal 10A - CV + Motivatiebrief - 4 jaar - Bepaalde tijd - Geen assessment - geen meeloopdag - Salaris: €3.217-€4.077 per month - Solliciteer voor 25 oktober 2026 Jouw functie Within the Thrombosis and Hemostasis research group of the Laboratory of Hematology, we investigate the mechanisms that maintain the delicate balance of the hemostatic system. Disruption of this balance may result in either bleeding or thrombosis, both of which represent major causes of morbidity and mortality worldwide. Bleeding following trauma remains one of the leading causes of death in individuals under the age of 46 years, while thrombotic diseases are among the most common causes of mortality globally, with incidence increasing with age. Identifying the cause of a bleeding tendency remains a major challenge in clinical hematology. Despite extensive laboratory and genetic investigations, no underlying hemostatic defect can currently be identified in approximately 50% of these patients. This may be further improved by evaluating clot degradation (fibrinolysis). However, assays assessing fibrinolytic capacity are poorly standardized and are not routinely available in clinical practice. In this PhD project, you will contribute to advancing our understanding of unexplained bleeding disorders through a combination of genomic analysis, functional characterisation and translational research approaches. The project aims to identify and characterize novel genetic variants and biological mechanisms underlying bleeding phenotypes by integrating whole-genome sequencing with functional studies in individual patients and affected families. In parallel, the project focuses on improving diagnostic strategies for fibrinolytic disorders by characterizing current diagnostic modalities and by developing, optimizing, and validating nov...