About this role
The Associate Research Grade Production’s duties shall include, but not be limited to: • Primary responsibility will be to produce research grade mRNA-LNPs, including lipid stock preparation, mRNA encapsulation (e.g., microfluidic mixing), buffer exchange/purification, concentration and sterile filtration. • Perform in-process and release characterization of LNP formulations (e.g., particle size and polydispersity by DLS, zeta potential, encapsulation efficiency and mRNA content by RiboGreen assay, pH and osmolality). • Prepare, aliquot and store LNP batches under appropriate conditions and follow up on their stability. • Execute new techniques/assays and support the optimization and scale-up of formulation processes.Work collaboratively with other departments (mRNA production, QC, Process Development) and/or project managers. • Maintain appropriate files related to ongoing formulations. Write formulation protocols, batch records, analytical test methods and reports if necessary. • Keep track of QC results of ongoing productions.