About this role
Logo of EURAXESS Job offer - JOB - Netherlands - University of Amsterdam (UvA) via AcademicTransfer - Posted on: 3 September 2026 PhD candidate "When vascular clearance fails: can brain networks be restored?" Page contents 3 Sep 2026 University of Amsterdam (UvA) Research Field First Stage Researcher (R1) Type of Contract Temporary Job Status Not Applicable Hours Per Week 38.0 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Are you looking for a neuroscience PhD project with clear clinical relevance? Do you want to study how brain networks become disrupted and how we might restore them? Are you excited to test novel interventions that target both vascular and neural circuits? Then this might be the chance to satisfy your curiosity. Join Us! We are looking for an enthusiastic PhD candidate to work on a research project funded by the Swammerdam Institute for Life Sciences, which aims to investigate how neurovascular deficits and aging affect brain circuits involving the thalamus. This is what you will do Cerebrovascular dysfunction, such as loss of the endothelial transporter lipoprotein receptor-related protein 1 (LRP1), which clears a variety of compounds from the brain, including amyloid beta, is increasingly recognized as a major driver of cognitive decline, increased excitability, epilepsy, and Alzheimer's disease (AD) pathology. However, how microvascular pathology impacts brain wide networks, including thalamus, cortex, hippocampus and cerebellum, remains largely unknown. In this PhD project, you will test the overarching hypothesis that endothelial LRP1 loss in mice disrupts brain wide networks, leading to impaired coherence, increased excitability, disturbed sleep patterns, and exacerbated amyloid pathology. Furthermore, you will test whether enhancing cAMP/cGMP s...