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Senior Scientist, Developability [Contract] @ BigHat Biosciences

San Mateo, CA, CAOnsiteFull-time
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About this role

The role: BigHat Biosciences is looking for a hands-on, bench-driven scientist to perform IND-enabling developability assessments on late stage drug candidates from our Milliner Platform for AI-designed therapeutics. This is a lab-based 12-month contract role , with the possibility but no guarantee of conversion to full-time position. You'll spend the majority of your time at the bench executing complex stability studies. Lead, design, and execute in-use dose solution studies to assess drug compatibility with administration materials. Develop highly sensitive protein characterization methods (qSEC, RP-HPLC, CEX, particle counting, etc) for assessing drug quality and recovery. Support late-stage characterization, including formulation screening, stress testing, and peptide mapping, to rank and advance lead candidates. Drive developability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization. Communicate with and manage external CROs for testing and analytics. Interpret and communicate scientific findings, propose next steps, and broadcast clearly across the organization. Proactively identify and scope state-of-the-art analytical tools and developability technologies.

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