About this role
UMC Utrecht Utrecht €3.724 - €5.876 36 uur WO Gisteren PostDoc to discover and characterize new inhibitory receptors in autoimmunity UMC Utrecht Salaris €3.724 - €5.876 Uren 36 uur Dienstverband Tijdelijk Werk locatie Utrecht Opleidingsniveau WO Branche Gezondheidszorg/Welzijn Functieomschrijving A 1(+2)-year position for a PostDoc in a project to discover and characterize new inhibitory receptors in autoimmunity. Dit ga je doen We invite highly motived PostDoc with experience in cellular immunology and an interest in academic-industry collaborations to apply. This is an industry funded PostDoc position set for intensive collaboration between the Inhibitory Receptor Lab and an industrial partner. Blockade of Inhibitory receptors have revolutionized cancer treatment by unleashing immune responses to cancer. The reverse strategy can potentially be used in autoimmunity to suppress unwanted inflammatory responses by engaging inhibitory receptors on immune cells. The first clinical studies show proof-of-concept, but in addition highlight the need to further improve these therapies. We previously computationally identified ~400 putative inhibitory receptors encoded in the human genome. In collaboration with an industrial partner, we will short-list putative inhibitory receptors for functional characterization. You will perform cellular assays to detail the expression and function of these candidates using CRISPR/Cas9 in primary human cells. Based on these results, we will make a 'deep dive' into a select set of candidates on immune cells of controls and patients with autoimmune diseases. You will be responsible for developing and conducting research at the UMCU, the communication between partners, and reporting to the industrial partner. Hier ga je werken You will part of the Inhibitory Receptor Lab that is led by Dr. Michiel van der Vlist and Prof. Linde Meyaard. The Inhibitory Receptor Lab is situated in Ce...