About this role
Summary The Center for Drug Discovery ( https://www.bcm.edu/research/centers/drug-discovery) is a strategic research center at Baylor College of Medicine in Houston, Texas. The lab is looking for a highly self-motivated Postdoctoral Research Associate with extensive experience in liquid chromatography–mass spectrometry (LC–MS) metabolomics, lipidomics, and drug metabolism. The Postdoctoral Associate will apply advanced MS-based approaches to study the proteosome and metabolome to characterize our newly created dTAG-KI animal models and conduct the drug metabolism pharmacokinetics studies. The lab is well-equipped with Thermos UHPLC-Q Exactive MS, Orbitrap Exploris™ 120, Thermo Quintus (triple quadruple), and Imaging mass spectrometry (IMS, Bruker timsTOF fleX MALDI-2). The position provides opportunities for advanced training in mass spectrometry, metabolomics, lipidomics, drug metabolism, toxicology, and imaging mass spectrometry within a collaborative and multidisciplinary research environment. Baylor College of Medicine typically follows similar to the NIH stipulated stipend guidelines for Postdoctoral Associates. Job Duties Develops, optimizes, and validates LC–MS and LC–MS/MS methods for metabolomics, lipidomics, drug metabolism, and biomarker analysis. Performs sample preparation and extraction of metabolites, lipids, drugs, and drug metabolites from cells, tissues, plasma, and other biological matrices. Conducts untargeted and targeted metabolomics and lipidomics studies. Processes, analyzes, interprets, and visualizes complex mass spectrometry datasets using appropriate computational and statistical tools. Performs in vitro drug-metabolism studies that includes incubations with liver microsomes, primary human hepatocytes, and other relevant biological systems. Identifies and characterizes drug metabolites using high-resolution mass spectrometry and tandem mass spectrometry. Assesses cellular toxicity using biochemical, molecular, imaging, and metabolomics-based endpoints. Maintains accurate experimental records and contributes to data interpretation, scientific presentations and manuscripts. Performs other job-related duties as assigned. Minimum Qualifications MD or Ph.D. in Basic Science, Health Science, or a related field. No experience required. Preferred Qualifications PhD or equivalent doctoral degree in analytical chemistry, pharmacology, pharmaceutical sciences, biochemistry, metabolomics, or a related discipline. Demonstrated expertise in metabolomics and/or lipidomics, including sample preparation, instrument operation, data processing, and biological interpretation. Experience with high-resolution LC–MS platforms, especially Thermo Orbitrap Exploris MS. Proficiency with metabolomics and lipidomics data-analysis software and multivariate statistical methods. Experience with primary human hepatocytes or other physiologically relevant cell models. Experience with imaging mass spectrometry, including MALDI or DESI imaging, would be a significant advantage. Experience with mammalian cell culture and drug-induced toxicity studies. Strong publication record in mass spectrometry, metabolomics, lipidomics, drug metabolism, toxicology, or related fields. Strong organizational, analytical, troubleshooting, and scientific communication skills.