About this role
School of Medicine Established in 1930, Duke University School of Medicine is the youngest of the nation's top medical schools. Ranked sixth among medical schools in the nation, the School takes pride in being an inclusive community of outstanding learners, investigators, clinicians, and staff where interdisciplinary collaboration is embraced and great ideas accelerate translation of fundamental scientific discoveries to improve human health locally and around the globe. Composed of more than 2,600 faculty physicians and researchers, nearly 2,000 students, and more than 6,200 staff, the Duke University School of Medicine along with the Duke University School of Nursing, and Duke University Health System comprise Duke Health, a world-class academic medical center. The Health System encompasses Duke University Hospital, Duke Regional Hospital, Duke Raleigh Hospital, Duke Health Integrated Practice, Duke Primary Care, Duke Home Care and Hospice, Duke Health and Wellness, and multiple affiliations. Be You. Postdoctoral Associate Boyce Lab, Duke University School of Medicine The Boyce Laboratory in the Department of Biochemistry at Duke University seeks a talented, motivated, and collegial postdoctoral fellow to join a newly funded NINDS R01 project investigating how O-GlcNAc glycosylation regulates KLHL-family E3 ubiquitin ligases (gigaxonin, KLHL3) and their substrates (neurofilaments, WNK kinases) in neuronal proteostasis, cytoskeletal dynamics, and ferroptotic cell death. This collaborative work combines biochemistry, chemical biology, cell signaling, live-cell imaging, and organotypic brain slice models to dissect the mechanistic links between intracellular glycosylation and neurodegeneration. By mutual agreement with the PI, the exact portfolio within the larger project may be adjusted to suit the postdoc’s background, interests, and professional goals. Qualifications We are looking for a candidate with a Ph.D. or equivalent doctoral training in biochemistry, cell biology, neuroscience, or a related field, who is intellectually curious, works well independently and as part of a team, and is committed to rigorous, reproducible science. Research experience in cellular neurobiology and/or O-GlcNAc signaling or glycobiology more broadly is strongly preferred but not strictly required. This position is onsite. The work is performed on-site or at a designated assignment location. Be Bold. The successful candidate will have access to a rigorous, well-funded, inclusive, and highly collaborative research environment with state-of-the-art core facilities and opportunities to develop independent expertise across multiple experimental systems, from cell lines to primary neurons to ex vivo brain tissue. The postdoc will be encouraged to develop a unique scientific identity within the broader project, lead publications, present their work at national conferences, mentor junior researchers, and develop the skills and preliminary data needed for an independent research career in any sector. Choose Duke. Scientists with strong backgrounds in adjacent areas and a firm commitment to learning glycobiology approaches are also encouraged to apply. Interested candidates should include a CV, brief statement of research interests, and contact information for three references in their applications. Duke is an Equal Opportunity Employer committed to providing employment opportunity without regard to an individual's age, color, disability, gender, gender expression, gender identity, genetic information, national origin, race, religion, sex (including pregnancy and pregnancy related conditions), sexual orientation or military status. Duke aspires to create a community built on collaboration, innovation, creativity, and belonging. Our collective success depends on the robust exchange of ideas—an exchange that is best when the rich diversity of our perspectives, backgrounds, and experiences flourishes. To achieve this exchange, it is essential that all members of the community feel secure and welcome, that the contributions of all individuals are respected, and that all voices are heard. All members of our community have a responsibility to uphold these values. Essential Physical Job Functions: Certain jobs at Duke University and Duke University Health System may include essential job functions that require specific physical and/or mental abilities. Additional information and provision for requests for reasonable accommodation will be provided by each hiring department.