About this role
Join AbbVie’s Biologics Discovery Sciences group and make a tangible impact in advancing innovative biologic therapies. As a scientist specializing in Biologics Purification, you will play a pivotal role in driving drug discovery, collaborating within a dynamic team dedicated to supporting transformative science that improves patient lives worldwide. Your expertise will help deliver high-purity multi-specific antibody-based biologic candidates with suitable purity/characteristics to support the advancement of vital in vitro (i.e. drug-like property assays, binding, cell-based assays, etc.) and in vivo studies (i.e. efficacy, non-GLP NHP PK, DRF, etc.).
Key Responsibilities:
Lead small-scale (<1L) purification of multi-specific antibody biologics to support critical research assays and studiesDesign and execute advanced chromatography techniques and robust bioprocess development strategies to address production impurities and liabilities to deliver high quality antibody biologics to therapeutic areasExecute rigorous analytical characterization of molecules, end products, by-products, and process intermediatesApply Design of Experiments (DOE) with high throughput automation to optimize chromatography conditions for enhanced separation and resolution of complex protein mixturesDrive innovation to support continuous improvement in downstream biologics processes and advance automation initiativesCollaborate with multidisciplinary teams, translating molecular insights into functional resultsPresent findings clearly to diverse audiences and document results with rigor BS, MS, or PhD in Bioinformatics, Biophysics, Chemical Engineering, or related field with typically 8-10 years (BS), 5-7 years (MS), or 0-3 years (PhD) of experienceDeep proficiency in bioprocessing, column chromatography, and antibody-based biotherapeutics manufacturing is requiredExpertise with AKTA chromatography systems is requiredExperience operating high throughput automated liquid handling systems for chromatography applications (i.e. plate-based screening, robocolumns) is highly preferredDemonstrated success designing and executing DOE studies with successful application to protein production scale-up is preferableFamiliarity with programming languages (i.e. Python) and developing Bioinformatics or AI/ML tools is a plusStrong understanding of molecular and post-translational attributes of biologicsExceptional analytical, communication, and presentation skillsCollaborative spirit and dedication to scientific excellence Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of thisposting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location,and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our long-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission,incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless anduntil paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
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