About this role
Your mission Engitix Therapeutics is a pioneering biotechnology company dedicated to unlocking extracellular matrix (ECM) biology to develop transformative therapeutics for fibrosis and oncology. We are seeking a motivated <strong>Scientist</strong> to join our Discovery team and support the development and execution of our proprietary extracellular matrix tissue assay platforms.<br><br>This is an exciting opportunity for a scientist with experience in handling human tissue, histology and cell-based assays to contribute to the development of innovative drug discovery models that bridge traditional in vitro systems and human disease biology.<br><br><strong>The Role </strong><br>As a Scientist, you will play a key role in establishing complex human ECM based assays to support target ID and validation. Working closely with scientists across biology, translational research and imaging, you will prepare and process human tissue samples, perform cell-based assays, generate high-quality imaging data and contribute to assay optimisation to support target screening. <br>This is a hands-on laboratory role with opportunities to develop expertise in advanced tissue models, high-content imaging and extracellular matrix biology within a collaborative drug discovery environment. <br><br><strong>Key Responsibilities</strong> <br><ul><li><span><span>Perform preparation and processing </span><span>including </span><span>decelluarisation </span><span>of human tissue samples for cell-based assays</span></span></li><li><span><span>Prepare tissue sections using standard histology techniques, including embedding, </span><span>sectioning </span><span>and staining</span></span></li><li><span><span>Execute cell-based assays using primary cells and established cell lines within ECM-based models</span></span></li><li><span><span>Support optimisation and validation of tissue-based drug screening assays</span></span></li><li><span><span>Perform immunofluorescence staining and prepare samples for high-content imaging and image analysis</span></span></li><li><span><span>Generate, </span><span>record </span><span>and analyse experimental data, </span><span>maintaining </span><span>accurate </span><span>laboratory records</span></span></li><li><span><span>Assist </span><span>with assay troubleshooting and implementation of process improvements</span></span></li><li><span><span>Work closely with multidisciplinary project teams to deliver experimental data to agreed timelines</span></span></li><li><span><span>Maintain laboratory equipment and contribute to good laboratory practice and health and safety compliance</span></span></li></ul> Your profile <strong><u>Qualifications and Competencies </u></strong><br><ul><li>BSc or MSc in Biomedical Sciences, Cell Biology, Biochemistry, Biotechnology or a related life sciences discipline</li><li>1–3 years of laboratory experience in academia, biotechnology or pharmaceutical research (industrial placement experience will also be considered)</li><li>Ability to plan and execute experiments with appropriate supervision</li><li>Strong problem-solving and troubleshooting skills</li><li>Strong written and verbal communication skills</li><li>A collaborative approach and enthusiasm for working in a multidisciplinary team</li><li>Ability to maintain accurate experimental records and work to high scientific standards</li></ul><strong><u>Key Experience</u></strong><br><strong>Essential</strong><ul><li>Practical laboratory experience handling human tissue samples</li><li>Experience with standard histology techniques, including tissue processing, embedding, sectioning and staining</li><li>Experience performing mammalian cell culture and cell-based assays</li><li>Experience with immunofluorescence microscopy or high-content imaging</li><li>Strong laboratory organisation and documentation skills</li><li>Excellent attention to detail and ability to generate reproducible experimental data</li></ul><strong>Desirable </strong><ul><li>Experience working with precision-cut tissue slices or other ex vivo tissue models</li><li>Knowledge of extracellular matrix (ECM) biology, fibrosis or tissue remodelling</li><li>Familiarity with high throughput imaging and analysis software</li><li>Experience working with primary human cells, particularly fibroblasts or immune cells</li></ul> Why us? <ul style="border:0px solid;margin:8px 0px;padding:0px 0px 0px 24px;color:rgb(31,31,31);font-size:14px;font-style:normal;font-weight:400;text-transform:none;font-family:Inter, '-apple-system', BlinkMacSystemFont, 'Segoe UI', Roboto, 'Helvetica Neue', 'Open Sans', 'system-ui', '-apple-system', 'Segoe UI', Roboto, Ubuntu, Cantarell, 'Noto Sans', sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji';background-color:rgb(255,255,255);"><li style="border:0px solid;margin:0px;font-family:Arial, Helvetica, sans-serif;list-style-type:disc;font-size:14px;">Be part of a pioneering biotech transforming drug discovery through ECM biology</li><li style="border:0px solid;margin:0px;font-family:Arial, Helvetica, sans-serif;list-style-type:disc;font-size:14px;">Work in a collaborative, fast-paced environment with opportunities to shape the future of targeted therapeutics</li><li style="border:0px solid;margin:0px;font-family:Arial, Helvetica, sans-serif;list-style-type:disc;font-size:14px;">We offer a competitive package including private medical insurance, pension, bonus, employee perks and more!</li></ul>