About this role
Logo of EURAXESS Job offer AcademicTransfer - JOB - Netherlands - Posted on: 7 July 2026 Page contents 7 Jul 2026 Erasmus MC (University Medical Center Rotterdam) Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Application Deadline 14 Aug 2026 - 21:59 (UTC) Country Netherlands Type of Contract Temporary Job Status Not Applicable Hours Per Week 36.0 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No Offer Description Host institution:Erasmus University Medical Centre Rotterdam (EMC-a), Department of Molecular Genetics , Rotterdam, Netherlands Co-supervisors: Prof. Thierry Voet, Katholieke Universiteit Leuven, Department of Human Genetics, Belgium (Academic); Dr. Domenico Bellomo, SkylineDx B.V., Netherlands (Industry) Project description: DC2 will develop a 3D spatial FUN-G&T-seq and/or scNMT-seq workflow for multimodal profiling of melanoma models and tissue samples. The project will translate the protocol developed by DC3 into 3D melanoma organoid and immune cell co-cultures, fresh 200-400 μm tissue sections or explant samples. It pursues two integrated objectives: i) establish a methodology for 3D spatial FUN-G&T-seq and/or spatial scNMT-seq; ii) apply this workflow to profile tumour and immune cells in melanoma organoid co-cultures and live tissue slices. At Erasmus MC, the candidate will work to combine spatial FUNseq with single-cell genome and transcriptome sequencing and/or single-cell nucleosome, methylation and transcriptome sequencing. The workflow will be adapted to 3D light-sheet microscopy and thick melanoma samples, addressing challenges linked to image quality, cell selection, tissue depth and multimodal data integration. During a secondment with Dr. Chien's group, the candidate will receive training in spatial FUNseq and image-...