About this role
Select how often (in days) to receive an alert: PhD Candidate: The vicious circle of protein modification-induced chronic inflammation Welcome to Maastricht University! What if cardiometabolic and autoimmune diseases share a root cause? Join a cutting-edge collaboration uncovering how post-translational protein modifications ignite chronic inflammation and how we can intervene. For our Zon-MW funded project we invite 2 enthusiastic PhD candidates, one based at the Maastricht University and one at the Leiden University Medical Centre. PhD Candidate: The vicious circle of protein modification-induced chronic inflammation - Our goal: In this project, you will explore how post-translationally modified proteins and their antibodies contribute to chronic (low grade) inflammation and the development of cardiometabolic diseases. By studying complement activation and is association with (sub)clinical phenotypes using data from The Maastricht Study, you will help clarify their relevance in the etiology of disease. - Your colleagues: You will be embedded in a collaborative research environment at Maastricht University, working closely with researchers within the local team. You will also collaborate with researchers and a fellow PhD candidate at Leiden University Medical Centre in the research group of Prof Dr L.T. Trouw, with regular joint meetings and exchange visits as an integral part of the PhD programme. The PhD candidate based in Leiden will focus on the experimental and translational components of the project thereby complementing the human data analyses performed in Maastricht. Post-translationally modified proteins (PTMs) and their antibodies have been long-implicated in the etiology of auto-immune disease. Notably, PTMs and anti-PTMS are also found in other non-communicable diseases, but their pathophysiological relevance needs to be firmly established. In this PhD project, you will explore how activation of the complement...