About this role
We announce 80%, one-year extendable researcher position in the CRISPR gene therapy group led by Emma Haapaniemi to be based at NCMBM, University of Oslo & Oslo University Hospital. We welcome applications both from recent PhD graduates and more experienced scientists. The successful candidate will join a highly integrated and motivated team with diverse skills and expertise across molecular biology and immunology. The work tasks will concentrate on optimizing and scaling up protocols for efficient mutation correction in human T cells and hematopoietic stem cells utilizing CRISPR-Cas9 gene editing technologies. Examples of work tasks include optimization of patient-derived T cell and stem cell ex vivo editing & culturing conditions; establishing functional assays; design and optimizing high-throughput biology experiments in robotics platforms; setting up custom Next Generation Sequencing libraries and technologies; scale up protocols to pre-GMP and GMP scaleAbout the laboratory The aim of the Haapaniemi group (www.haapaniemilab.org) is to build a gene editing platform that can be used to correct patient-specific mutations in ex vivo cell therapies for genetic immune and other rare childhood diseases. We use high-throughput biology techniques to optimize, develop and understand the CRISPR-Cas9 system that forms the base of the platform, and develop and implement methods to evaluate its safety in a clinical setting. We will use gene editing technologies for the benefit of the patients in Nordic hospitals. Norwegian Centre for Molecular Biosciences and Medicine (NCMBM) was established in 2008 and is the Norwegian node in the Nordic EMBL Partnership for Molecular Medicine. NCMM is a joint venture between the University of Oslo, Health Region South-East and the Research Council of Norway, and has altogether 11 research groups. The overall objective of NCMM is to conduct cutting edge research in molecular medicine and biotechnology as well as facilitate translation of discoveries in basic medical research into clinical practice.Oslo University Hospital is a workplace with great diversity. We believe this is crucial for solving our tasks in the best possible way. We want this diversity to be reflected among the applicants for our positions, and we encourage all qualified candidates, regardless of background, to apply!