About this role
Group Overview:
The Analytical Development group within the Targeted LNP (tLNP) CMC Team at AbbVie is dedicated to advancing state-of-the-art analytical capabilities for mRNA-lipid nanoparticle therapeutics. Our team provides critical support across drug substance (DS) and drug product (DP) manufacturing, drug product formulation, and the development and implementation of robust analytical methodologies to ensure the quality, safety and integrity of tLNP genetic medicines. We leverage advanced biophysical, separations, and mass spectrometry techniques to deeply characterize intact LNP particles. We foster close collaborations with cross-functional colleagues in CMC, drug product formulation, and external partners, and are currently growing a world-class team of scientists who will be instrumental in building and deploying the analytical toolbox necessary to deliver high-quality, innovative tLNP medicines to patients.
Position Description:
As an Electrophoresis SME within the Analytical Development team of AbbVie’s Targeted LNP (tLNP) CMC organization, you will be a technical leader for the development, optimization, and qualification of Electrophoresis related methods that measure the mRNA and tLNP. The successful candidate will have hands-on analytical method development experience for Electrophoresis related methods (e.g.,CE, cIEF,CZE). Additionally, the candidate must foster productive collaborations within the global Analytical CMC organization and with R&D cross-functional partners such as Discovery, Pre-Clinical Safety, Process Chemistry, Process Engineering, Drug Product Development, and Quality Assurance and CMC-Regulatory Affairs.
Responsibilities:
Effectively function as a SME for Electrophoresis methods, generating original technical ideas and research or development strategies.Develop and optimize CE-LIF for assessing mRNA purity, qualify the methods for phase appropriate useExplore the potential of different electrophoresis methods to analyze mRNA-LNP size, degradation, purity and encapsulation efficiencyLead tech transfer, implementation and lifecycle management of Electrophoresis related methods (e.g., CE, icIEF,CZE)Generate new scientific proposals and lead those effortsDemonstrated ability to collaborate effectively with team members and a willingness to continuously learn new techniques to enhance and advance the analytical capabilities of the programDemonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the labEmbraces the ideas of others, nurtures innovation and manages innovation to realityUnderstand and comply with AbbVie safety, quality and regulatory policies and government regulations Scientist II: Analytical Chemistry degree (or related field). BS with 7+ years', MS with 5+ years' industry experience. Senior Scientist I: Analytical Chemistry degree (or related field). BS with 10+ years', MS with 8+ years', and PhD with 0+ years' industry experience. Deep understanding of the Electrophoresis principle, familiar with PA800+ / BioPhase 8800 / Maurice instruments and have hands on experience on at least one of these three instrumentsUnderstand the effects of key variables on method performance and utilize DOE approaches to achieve robust method developmentDirect experience developing, qualifying, and transferring Electrophoresis related methods for at least one of the following modalities: mRNA, antibody, LNPAbility to coordinate and help trouble shoot Electrophoresis analysis work at external CDMOs or contract testing labs.Hands-on experience with additional analytical techniques relevant to mRNA or LNP analysis is considered a plus.Working knowledge of biosafety, data integrity, and compliance requirements for GxP-regulated testing.Strong presentation and communication skills with the ability to explain data to technical and non-technical audiences. Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
Note: No amount of pay is considered to be wages or compensation until such amount is earned, vested, and determinable. The amount and availability of any bonus, commission, incentive, benefits, or any other form of compensation and benefits that are allocable to a particular employee remains in the Company's sole and absolute discretion unless and until paid and may be modified at the Company’s sole and absolute discretion, consistent with applicable law.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.
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