Senior Associate Scientist, Medicinal Chemistry Overview We are seeking a talented and passionate scientist to join our dynamic, fast-paced, and collaborative team. Using strong organic synthesis skills, you will contribute to developing and supporting novel chemistry solutions for the advancement of our RNAi platform. The successful candidate will have a strong background in synthetic Organic Chemistry with a creative mindset, independent problem-solving ability, and desire to enable discoveries at the bench. This position is onsite and will be primarily located in Cambridge, MA. Key Responsibilities <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Develop and execute syntheses of novel chemical modifications and delivery modalities for siRNA</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Multi-step synthesis, purification, and structural analysis of intermediate compounds</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Synthesis of organic building blocks to be used for RNA delivery</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Work closely with our internal RNAi platform teams and external collaborators to discuss project plans and coordinate activities for delivery and activity determination of siRNA</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Troubleshoot and perform routine maintenance on critical instrumentation such as NMR, HPLC, LCMS and other instruments in the lab</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Analyze, interpret, and organize data to prepare clearly articulated experimental reports and communicate the results of the projects at internal meetings </li> </ul> Qualifications <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">The ideal candidate will have a B.S./M.S. in Chemistry and 2-3 years of industrial experience in Medicinal Chemistry</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Demonstrated ability to understand reaction mechanism and chemical reactivity in Organic Chemistry is a must</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Strong laboratory skills in synthesis, purification, and characterization of small molecules</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Expertise in state-of-the-art analytical techniques such as LC, MS, NMR, and the ability to analyze, interpret, and present data are a prerequisite</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Must be flexible to be able to apply her/his knowledge to new areas of study, thrive in a team environment, and possess excellent communication skills (both written and oral) </li> </ul> #LI-JR1U.S. Pay Range $80,000.00 - $120,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: <a title="" href="https://www.alnylam.com/careers" target="_self">https://www.alnylam.com/careers</a> About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Senior Associate Scientist, Medicinal Chemistry (Cambridge, MA, US, 02142) @ Alnylam Pharmaceuticals, Inc.

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