About this role
<p><strong>Overview</strong></p> <p> </p> <p>The Associate Director, Clinical Pharmacology supports a rapidly expanding clinical portfolio of RNAi therapeutics within the CNS franchise. This role provides clinical pharmacology expertise across clinical-stage programs, with a strong focus on pharmacokinetics (PK), pharmacodynamics (PD), and PK/PD analyses to inform clinical development and regulatory decision-making.</p> <p> </p> <p>The position requires strong scientific expertise, critical thinking, and the ability to independently interpret and integrate complex clinical pharmacology data within a highly matrixed environment. The Associate Director partners closely with Research, Clinical Development, Bioanalytical, Regulatory, Project Management, and other R&D functions, contributing to clinical study design, data analysis, regulatory submissions, and scientific publications in support of advancing innovative RNAi therapies.</p> <p> </p> <p>This is a virtual role based in The Netherlands or UK. </p> <p> </p> <p><strong>Key Responsibilities</strong></p> <p> </p> <ul> <li>Represent independently Clinical Pharmacology and provide clinical pharmacology support and guidance to clinical stage project teams.</li> <li>Lead the analysis, interpretation, integration and reporting of clinical pharmacology data</li> <li>Conduct PK and PK/PD analyses to guide clinical development decisions</li> <li>Provide clinical pharmacology input for regulatory submissions such as briefing documents, IND, CTA and NDA</li> <li>Prepare and input independently appropriate documents or sections of clinical protocols, Investigator Brochures, Clinical Study Reports with respect to Clinical Pharmacology studies or data</li> <li>Closely partner with Research, Bioanalytical, Clinical, Regulatory, Project Management, and other R&D functions</li> <li>Preparation of abstracts and manuscripts for publications</li> </ul> <p> </p> <p><strong>Qualifications</strong></p> <p> </p> <ul> <li>Ph.D. ( or Pharm.D.) in relevant field (i.e. Pharmacokinetics, Pharmacometrics, Clinical Pharmacology) with in depth experience in pharmaceutical/biotech industry</li> <li>In depth knowledge of clinical pharmacology, pharmacokinetics, modeling and simulation, PK/PD principles, ADME and clinical data interpretation</li> <li>In depth knowledge of international guidelines related to Clinical Pharmacology and Pharmacometrics</li> <li>Proficient in using Phoenix WinNonlin, R, NONMEM, or other pharmacokinetic, modeling and data visualizations software.</li> <li>Ability to function in a highly matrixed team environment is essential</li> <li>Ability to work independently</li> <li>Strong communication and presentation skills (verbal and written)</li> <li>Excellent interpersonal skills and ability to work independently</li> <li>Fluency in English (verbal and written)</li> </ul> <p> </p> <p><strong>Why Alnylam?</strong></p> <p> </p> <p>Join a company recognized for its innovation, open culture, and commitment to people. At Alnylam, you’ll work in an environment that values collaboration, purpose, and excellence — and be part of a team bringing groundbreaking RNAi therapies to patients in need.</p> <p> </p> <p>Apply now to make a difference where science meets purpose.</p>