Overview We are seeking a scientist to join our Investigative Sciences team to help advance our RNAi therapeutics platform by elucidating mechanisms of toxicity and de-risking siRNA ligand candidates through hypothesis-driven, translational investigations. This role will work closely with platform research scientists, DMPK and Bioanalytical Sciences (BA) colleagues to support novel ligand derisking efforts that ensure candidate selection and transition to early development. Candidate would be expected to perform toxicological evaluations of siRNA ligands and elucidate of mechanisms of toxicity utilizing novel in vitro and/or in vivo systems. This position is onsite and will be primarily located in Cambridge, MA. Key Responsibilities <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Design and execute hypothesis-driven mechanistic in vitro studies to investigate toxicity findings.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Development and optimization of in-house in vitro models to support RNAi platform and novel ligand candidate derisking. Working with external vendors on technology and assay evaluation, where appropriate, also expected.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Assess and implement new technologies to support/improve compound toxicity prediction & screening. Preference toward high-throughput or genomics platforms.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Collaborate closely with discovery scientists, toxicologists, and pathologists to deconvolute toxicology issues and ensure strategic investigative alignment for candidate selection.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Communicate study rationale, results, and recommendations through high-quality reports, presentations, and cross-functional meetings.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Maintain high standards of scientific rigor, data integrity</li> </ul> Qualifications <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Ph.D. degree in Immunology, Molecular Toxicology, Pharmacology, or related field; 1-3 years relevant experience in academia or industry is preferred.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Experience with microphysiological systems (i.e. organ-on-chip, organoids, or iPSC models) is desired. </li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Demonstrated knowledge in designing and conducting in vitro mechanistic studies. </li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Technical proficiency in standard cellular and molecular biology techniques. Experience with high-content imaging and/or flow cytometry preferred.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Must be a highly motivated and organized individual with team orientated mentality and enjoy working in fast-paced and collaborative environment.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Excellent written and oral communication skills.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Experience with modalities such as small molecules and biologics preferred.</li> </ul> #LI-JR1U.S. Pay Range $110,400.00 - $165,600.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: <a title="" href="https://www.alnylam.com/careers" target="_self">https://www.alnylam.com/careers</a> About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Scientist, Investigative Sciences (Cambridge, MA, US, 02142) @ Alnylam Pharmaceuticals, Inc.

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