Overview We are looking for a highly motivated Principal Associate Scientist to join our Research Analytics group and contribute to the further exploration of RNAi therapeutics. The successful candidate will help to support siRNA design and discovery through implementation of existing and novel analytical methods. Areas of focus include understanding in vivo/in vitro metabolism of siRNA in relevant tissue and cell types using established analytical methods, exploring stability of novel siRNA conjugates for targeted delivery, and developing robust analytical methods for early CMC work. This position is onsite and will be primarily located in Cambridge, MA. Key Responsibilities <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Utilize analytical techniques such as hybridization ELISA, MSD, ELISA, HPLC, Gel Electrophoresis, and Western Blot to support pharmacokinetic and stability analysis of siRNA.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Effectively troubleshoot and optimize assay conditions and sample preparation protocols to improve assay sensitivity, specificity, and reproducibility.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Analyze and interpret ligand binding assay data to provide PK insights to present to team members.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Improve upon and/or develop new methods and automation for analysis of siRNA accumulation and stability. </li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Collaborate closely with cross-functional teams including PK/PD, bioanalytical, and discovery groups to integrate assay results.</li> </ul> Qualifications <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Bachelor’s or Master’s degree in Chemistry, Biochemistry, or a related field.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">5-8 years of work experience, preferably in an industrial setting. </li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Attention to detail with a commitment to accuracy and quality in experimental execution and design is highly preferred</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Hands-on experience with ligand binding assays (e.g., hybridization ELISA, MSD, ELISA) is highly preferred.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Familiarity with bioanalytical techniques and instrumentation for PK analysis is preferred.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Experience with assay optimization, validation, and troubleshooting is preferred.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Familiarity with instrumentation such as HPLC, Gel Electrophoresis, etc. is preferred. </li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Ability to function within a highly interdisciplinary environment is a must.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Excellent written and oral communication skills, good organization skills, the ability to multitask, and the ability to work within a team and/or independently are required.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Strong commitment to high laboratory and scientific standards and the ability to maintain a safe, clean, and orderly laboratory work environment</li> </ul> #LI-JR1U.S. Pay Range $95,600.00 - $143,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: <a title="" href="https://www.alnylam.com/careers" target="_self">https://www.alnylam.com/careers</a> About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Principal Associate Scientist, RNAi Discovery (Cambridge, MA, US, 02142) @ Alnylam Pharmaceuticals, Inc.

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