Overview We are looking for a highly motivated, enthusiastic, and innovative candidate for the role of Senior Associate Scientist of Lipid Nanoparticle (LNP) formulations within Formulation Sciences team. The candidate must be independent, goal oriented, technically competent, and able to efficiently work across multiple projects. The successful candidate will have scientific background in LNP formulations, as well as drug delivery systems and analytical techniques. They should be an independent problem-solver, collaborative, and comfortable working in a fast-paced entrepreneurial environment. This position is onsite and will be primarily located at 675 W Kendall St, Cambridge, MA 02142. Key Responsibilities <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Conduct LNP formulation optimization and characterization </li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Support in vitro/in vivo studies by producing LNPs encapsulating siRNAs and/or mRNAs </li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Generate analytical data to understand physicochemical parameters of LNPs across various payloads and to support projects in research/development</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Support novel method development of LNP characterization and LNP delivery</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Support the development and characterization of formulations across diverse therapeutic modalities (e.g., antibody-oligonucleotide conjugates and other emerging modalities) within the Formulation Sciences team.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Design, plan and perform scientific experiments and contribute to project related scientific activities with some guidance from team members</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Analyze, summarize experimental data, and present scientific findings in the cross-functional teams</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Maintain electronic lab notebook, SOPs, appropriate documentation for scientific data and experimental protocols </li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Work closely with scientists in Medicinal Chemistry, RNAi biology, and early development teams</li> </ul> Qualifications <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">BS/MS in Chemical Engineering, Material Science and Engineering, Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline with 2-4 years of industry experience with a focus on LNP formulation and delivery systems</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Direct experience in LNP formulation (in-line mixing and TFF), characterization (DLS, NTA, zeta potential, UV/fluorescence spectroscopy, HPLC, UPLC, ribogreen assay, capillary electrophoresis, gel electrophoresis, etc.), mRNA and siRNA encapsulation, and QC analysis is a must</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Experience in high-throughput formulation screening will be plus</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Experience in antibody, peptide, or small molecule formulations/analysis and drug delivery systems will be plus</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Ability to work on multiple projects simultaneously and deliver conclusive results</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Ability to quickly adapt to new priorities with responsibility in a fast-paced, dynamic, innovative environment</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Goal oriented, highly organized with significant attention to details while maintaining highest scientific and ethical standards </li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Strategic and forward thinking</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Strong team player with excellent verbal and written communication skills</li> </ul> #LI-JR1U.S. Pay Range $80,000.00 - $120,000.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: <a title="" href="https://www.alnylam.com/careers" target="_self">https://www.alnylam.com/careers</a> About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Senior Associate Scientist, LNP Formulations (Cambridge, MA, US, 02142) @ Alnylam Pharmaceuticals, Inc.

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