Overview We are seeking a highly motivated Sr. Scientist in Delivery Biology to support and advance targeted delivery strategies for siRNA–based therapeutics. This role will focus on mechanistic cell biology to improve specific delivery across tissues and cell types. The successful candidate will have excellent knowledge of cell biology with an expertise in vesicular trafficking. Experience in the field of antibody or other ligand oligonucleotide conjugates is a plus. The individual will need excellent collaboration and communication skills to work collaboratively across the research department. Key Responsibilities <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="line-height:15.0pt;margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Develop and apply assays and experimental strategies to interrogate trafficking biology </li> <li style="line-height:15.0pt;margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Design, execute, and interpret cell‑based assays to evaluate delivery efficiency and biological outcomes </li> <li style="line-height:15.0pt;margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Identify cell types or tissues that require novel or optimized delivery approaches </li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Collaborate extensively with cross‑functional partners focused on expanding targeted delivery into new cell types and tissues. </li> <li style="line-height:15.0pt;margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Transparently communicate data, conclusions, and experimental rationale to team members and leadership </li> <li style="line-height:15.0pt;margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Mentor and support the scientific development of junior scientists or research associates</li> </ul> Qualifications <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">PhD in Cell Biology, Molecular Biology, Immunology, Biochemistry or related field.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">2-3 years of experience in biophparma setting.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Strong expertise in cell biology, particularly intracellular trafficking, receptor biology, or related mechanisms.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Experience in microscopy and biochemical techniques related to cell-based studies</li> <li style="line-height:15.0pt;margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Experience designing and interpreting both in vitro and in vivo experiments</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Experience with ligand-based delivery, conjugates or receptor biology preferred.</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Demonstrated scientific rigor, attendtion to detail and data reproducibility. </li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Excellent communication and interpersonal skills, with the ability to effectively collaborate across multidisciplinary teams.</li> </ul> #LI-JR1U.S. Pay Range $126,400.00 - $189,600.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: <a title="" href="https://www.alnylam.com/careers" target="_self">https://www.alnylam.com/careers</a> About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Senior Scientist, Cell Biology (Cambridge, MA, US, 02142) @ Alnylam Pharmaceuticals, Inc.

About this role

Ready to apply?