Overview We are looking for a talented and highly motivated Associate Scientist II to join our RNA synthesis group and support our mission to deliver the next generation of RNAi-based medicines. The successful candidate will contribute to the synthesis, purification, and analysis of oligonucleotides in support of our growing RNAi drug development platform. In addition, they will expand the chemical repertoire of RNAi therapeutics through the synthesis, purification, and characterization of chemically modified oligonucleotides. This position is onsite and will be primarily located in Cambridge, MA. Key Responsibilities <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Design and execute high-throughput synthesis of modified oligonucleotides using automated platforms</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Carry out the downstream purification and analytical characterization of the synthesized oligonucleotides using instrumentation such as HPLC, LC-MS, UV-Vis</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Optimize and/or develop new synthetic methods to expand our synthetic capabilities</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Effectively troubleshoot synthetic/process issues and independently find solutions</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Analyze and interpret data to improve yield, purity, and process efficiency</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Maintain and troubleshoot essential lab equipment, coordinating servicing and repairs as needed</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Maintain clear, accurate, and timely experimental documentation</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Effectively work with team members to foster communication, culture, and efficiency</li> </ul> Qualifications <ul style="margin-bottom:0.0in;margin-top:0.0px"> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Bachelor’s in chemistry or a related discipline with 0-3 years of relevant experience, preferably in an industrial setting. Alternatively, Master’s in Chemistry or a related discipline with 1+ years of relevant experience, preferably in an industrial setting</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Prior experience with solid-phase synthesis (SPS) of oligonucleotides with deep understanding of the mechanisms and processes involved in SPS is a plus</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Experience with analytical instrumentation including HPLC (anion-exchange and reverse-phase), LC-MS, and UV-Vis</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Familiarity with laboratory automation (e.g. liquid handlers) is a plus</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Strong troubleshooting and process optimization skills</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Excellent written and oral communication skills, good organization, multitasking ability, and the ability to work within a team and independently are required</li> <li style="margin:0.0in 0.0in 0.0in 0.0px;font-size:12.0pt;font-family:'Times New Roman', serif">Strong commitment to high laboratory and scientific standards and the ability to maintain a safe, clean, and orderly laboratory work environment</li> </ul> #LI-JR1U.S. Pay Range $67,600.00 - $101,400.00 The pay range reflects the full-time base salary range we expect to pay for this role at the time of posting. Base pay will be determined based on a number of factors including, but not limited to, relevant experience, skills, and education. This role is eligible for an annual short-term incentive award (e.g., bonus or sales incentive) and an annual long-term incentive award (e.g., equity). Alnylam’s robust Total Rewards package is designed to support your overall health and well-being. We offer comprehensive benefits including medical, dental, and vision coverage, life and disability insurance, a lifestyle reimbursement program, flexible spending and health savings accounts and a 401(k)with a generous company match. Eligible employees enjoy paid time off, wellness days, holidays, and two company-wide recharge breaks. We also offer generous family resources and leave. Our commitment to your well-being reflects our belief that caring for our people fuels the impact we create together. Learn more about these and additional benefits offered by Alnylam by visiting the Benefits section of the Careers website: <a title="" href="https://www.alnylam.com/careers" target="_self">https://www.alnylam.com/careers</a> About Alnylam We are the leader in RNAi therapeutics – a revolutionary approach with the potential to transform the lives of people with rare and common diseases. Built on Nobel Prize-winning science, Alnylam has delivered the breakthroughs that made RNAi therapeutics possible and are just at the beginning of what’s possible. Our deep pipeline, late-stage programs, and bold vision reflect our core values: fierce innovation, passion for excellence, purposeful urgency, open culture and commitment to people. We're proud to be a globally recognized top employer, where an authentic, inclusive culture and breakthrough thinking fuel one another. At Alnylam, we commit to an inclusive recruitment process and equal employment opportunity. Qualified applicants will receive consideration for employment without regard to their sex, gender or gender identity, sexual orientation, race, color, ethnicity, national origin, ancestry, citizenship, religion, creed, physical or mental disability, pregnancy status or related conditions, genetic information, veteran or military status, marital or familial status, political affiliation, age, or any other factor protected by federal, state, or local law. Alnylam is an E-Verify Employer.

Associate Scientist II, Oligonucleotide Synthesis (Cambridge, MA, US, 02142) @ Alnylam Pharmaceuticals, Inc.

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