About this role
The Opportunity:
We are looking for a Post-Doctoral Research Assistant to join our team based at IGC (ECRC) for a one year post. Our lab studies mutations in the metabolic isocitrate dehydrogenase (IDH1/2) genes and this project focusses on how these mutations re-program liver cells, in the context of biliary cancer. We are using CRISPR-edited human cells and novel transgenic models in mice to examine how these mutations affect the liver’s response to damage and explore the link between injury and metabolic re-programming.
Ideally, the post holder should have experience of animal work, cell culture, tissue processing and will be able to perform laboratory analyses of human and mouse tissue including genotyping, IHC, rt-PCR, western blotting and prepare samples for external providers (transcriptomics, metabolomics). A large proportion of the work will be based on animal experiments; a PIL is a desired but not an essential requirement for the post. Experience of in vivo models of liver cancer and/or liver disease would be highly desirable.
This post is full-time (35 hours per week); however, we are open to considering part-time or flexible working patterns.
The salary for this post is £41,064 to £48,822 per annum.
Your skills and attributes for success:
A proactive, enthusiastic approach to science Ability to work both independently and as part of a team Experience of molecular techniques that may include (but not limited to) rt-PCR, IHC, genotyping and sample preparation for external providers Experience of tissue processing and cell culture
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Apply Before: 12/12/2025, 23:59