About this role
Supervisors:
Prof. Giorgio Volpe
Prof. Lena Ciric
Abstract
Horizontal gene transfer (HGT) is a major driver of antimicrobial resistance (AMR), yet most research focuses on well-mixed lab cultures rather than the structured biofilms found in real-world environments. This project investigates how engineered surface topographies influence HGT dynamics, aiming to develop design principles for materials that suppress resistance gene transfer. Combining biophysics, microbiology, and materials science, the project will generate insights into how physical environments can be harnessed to control AMR.
Approach and Methods
Soft lithography and microfabrication to create defined surface landscapes. • Mating assays between resistant and sensitive Enterobacteriaceae strains. • Live-cell imaging and fluorescent plasmid tracking. • Quantitative image analysis to assess spatial dynamics of gene transfer.
Impact and Outlook
This project will:
Establish proof of concept for surface-based AMR control. • Inform the design of antimicrobial hospital surfaces and medical devices. • Contribute to sustainable strategies for AMR mitigation.
Training and Student Development
The successful applicant will gain expertise in:
Microbial genetics and fluorescence imaging • Microfabrication and surface engineering • Quantitative microscopy and data analysis • Interdisciplinary collaboration across microbiology, engineering, and biophysics
Research Environment
Volpe Lab: Experts in active matter, microscopy and microfabrication, with a strong interdisciplinary focus. Ciric Lab: Leaders in healthy infrastructure and microbial surface interactions. Both labs foster collaborative, cross-disciplinary research and have a strong record of PhD supervision.
Desirable Prior Experience
Experimental biophysics and soft matter, optical microscopy, numerical methods, molecular biology methods (e.g. cloning, PCR) and bacterial plasmid mating.
How to apply
This project is offered as part of the Centre for Doctoral Training in Engineering Solutions for Antimicrobial Resistance. Further details about the CDT and programme can be found at AMR CDT webiste
Applications should be submitted by 12th January 2026.