About this role
Location: Old Road Campus, Oxford
About the role
We have an exciting opportunity to join the Rare Genetic Disorders Research Group led by Prof. Stephan Sanders in the Department of Paediatrics at the University of Oxford as a Postdoctoral Researcher.
The group aims to identify, understand, and develop therapies for rare genetic disorders. The group is primarily computational but partners with multiple international labs (including Harvard, Yale, UC San Francisco [UCSF], and the New York Genome Center) to co-design experiments and generate novel datasets, including exome/genome sequencing of hundreds of thousands of individuals, large-scale single-cell data from primary human tissues, spatial transcriptomic data, and experimental genomic screens.
The postholder will join a multidisciplinary team based in the Institute of Developmental & Regenerative Medicine (IDRM) in Oxford but also working at UCSF, and will contribute to both laboratory-based, computational, and analytical research.
This position is offered full-time on a fixed-term contract for one year, with the possibility to extend provided further external funding is available.
About the department
The Department of Paediatrics is committed to equality and valuing diversity. The Department of Paediatrics has been honoured with the Athena Swan Gold award, a national gender equality charter, recognising the Department's innovative policies and practices. We are committed to the professional development of our staff by providing up to ten paid days annually for skill enhancement and allowing applications for additional training funding. By joining us, you will have the opportunity to contribute to a forward-thinking department.
About you
We are seeking a talented and motivated Postdoctoral Researcher to join a multidisciplinary team investigating how splicing shapes the developing human brain and contributes to neurological and neurodevelopmental disorders. This role offers a unique opportunity to work at the forefront of therapeutic genomics, leveraging large-scale functional genomic datasets and cutting-edge computational resources, including university HPC clusters and AWS.
The position requires a PhD in a relevant field, strong bioinformatics and programming skills, excellent communication and organisational abilities, and experience working both independently and collaboratively, with additional merits including high-performance computing experience and expertise in human genetics, therapeutic approaches, or neurogenomic research. As part of the MRC Centre of Research Excellence in Therapeutics Genomics, you will contribute to research that directly informs the development of treatments for rare genetic disorders.
Please apply via the ‘Apply’ button above.
Only online applications received before 12.00 midday on Friday 19th December 2025 will be considered. Interviews will be held during the second or third week of January.